Hematological Manifestations of Infectious Disease Aravind Raj Sanjeevaiah MD*, Santhosh Sadashiv MD, Divya Bhargavi Mella MD, Neeta Pathe MD and Mary Claire Maxwell NP-C Assistant Professor, Department of Internal Oral manifestations of hematologic and nutritional deficiencies can affect the mucous membranes, teeth, periodontal tissues, salivary glands, and perioral skin. HEMATOLOGIC (BLOOD) DISEASES • Bleeding Disorders – Platelet Function – Coagulation Factor • Platelet Deficiency – Thrombocytopenia / Thrombocytopathia • Red Blood Cell (RBC) Disorders – Anemia • White Blood Cell (WBC) Disorders – – – Leukopenia … Our purpose was to compile information on the haematological manifestations of systemic lupus erythematosus (SLE), namely leucopenia, lymphopenia, thrombocytopenia, autoimmune haemolytic anaemia (AIHA), thrombotic thrombocytopenic purpura (TTP) and myelofibrosis. 2,5. Oral manifestations in patients with endocrine di-sorders (disorders of … 2, 3 Oral mucosa is an area susceptible to complications of 2 6. Mædica. Specific or non-specific oral manifestations of individual myeloid neoplasms that have oral manifestation are discussed below. Anemia and other blood diseases 2. Eating disorders are also characterized by intra‐oral and extra‐oral manifestations. Arunkumar KV, Kumar S, Deepa D. Brown tumor in mandible as a first sign of vitamin 16:310-5. Vitamin B[12] deficiency is often diagnosed with hematological manifestations of megaloblastic macrocytic anemia, which is usually the initial presentation. Fig. Red blood cell, white blood cell, and platelet disorders often lead to a large variety of hematologic effects in ocular tissues, and especially in the retina. Oral manifestations Oral lesions in CD are more frequent in young male pa-tients (3) and their prevalence can range from 20 to 50% (3,7,8). Objective To evaluate the frequency and types of oral … … To date, studies about SLE in Morocco are few. 2011; 15:S113-6. Hematological disorders were reported in 82.7% of patients with SLE in a study conducted in Saudi Arabia [ 1 ]. The most frequent intra‐oral manifestations are dental erosion, trauma to the mucosa of the oral cavity and pharynx, dry mouth, a heightened risk of caries, periodontal problems, and lesions to the soft tissues secondary to the emesis, or effects induced indirectly by vomiting systemically [ 1 ]. Electronic address: christina.mccord@schulich.uwo.ca. 2, 3 Oral mucosa is an area susceptible to complications of 2 Soft tissue findings Oral mucosa: Common reported manifestations in oral mucosa include mucosal pallor or erythema, ulcerations, hemorrhage, mucositis, severe recurrent viral, bacterial and fungal oral infection. A Flow diagram of the systematic literature review, indicating the process of record selection. anemia & other blood disease and its manifestations in oral cavity 1. Examination should include evaluation for mucosal changes, periodontal inflammation and bleeding, and general condition of the teeth. Oral findings of anemia may include mucosal pallor, atrophic glossitis, and candidiasis. Oral ulceration may be found in patients with lupus erythematosus, pemphigus vulgaris, or Crohn disease. Orofacial manifestations of hematological disorders: Anemia and hemostatic disorders Titilope A Adeyemo , Wasiu L Adeyemo , Adewumi Adediran , Abd Jaleel A Akinbami , Alani S Akanmu Departments of Haematology and Blood Transfusion and Oral and Maxillofacial Surgery, College of Medicine, University of Lagos, Nigeria For this reason, dentists play an important role in the detection of emerging autoimmune pathologies. Review articles Annals and Essences of Dentistry Vol. Oral Manifestations of Malnutrition III. The frequency of hematological disorders in SLE are the highest among all other manifestations in Saudi Arabia []. Soft tissue findings Oral mucosa: Common reported manifestations in oral mucosa include mucosal pallor or erythema, ulcerations, hemorrhage, mucositis, severe recurrent viral, bacterial and fungal oral infection. Oral manifestations of systemic disease. [1] Most of these manifestations are non-specific, but should alert the hematologist and the dental surgeon to the possibilities of a concurrent hematological disorder or a latent one that may subsequently manifest itself. Haematopoietic stem cell transplantationStem cells for transplantation can be sourced from the blood, bone marrow or umbilical cord blood. Common manifestations … HEMATOLOGICAL DISORDERS Presented by: Madiha Shanam Mariya Fatma BDS-Final Yr) (Batch-2016-17) RED BLOOD CELL DISORDERS RBC is biconcave in shape. Hematological manifestations There are various hematological changes encountered in a patient with COVID-19 disease. Oral manifestations of hematological disorders. Hematological findings and complications of COVID -19 Evangelos Terpos 1, Ioannis Ntanasis-Stathopoulos , Ismail Elalamy2,3, Efstathios Kastritis1, Theodoros N. Sergentanis1, Marianna Politou4, Theodora Psaltopoulou12,31 Transport of: › Gases, nutrients, waste products › Processed molecules › Regulatory molecules Regulation of pH and osmosis Maintenance of body temperature Protection against … Dermatological manifestations of HIV infection are diverse consisting of infections, inflammatory disorders and malignancies. Hematological Manifestations of Infectious Disease Aravind Raj Sanjeevaiah MD*, Santhosh Sadashiv MD, Divya Bhargavi Mella MD, Neeta Pathe MD and Mary Claire Maxwell NP-C Assistant Professor, Department of Internal Learn vocabulary, terms, and more with flashcards, games, and other study tools. In the US iron deficiency in men Main features include Dysphagia, iron deficiency anemia, dystrophy of nails (koilonychias). Oral manifestations include atro pi c Oral supplements of iron in the form of ferrous sulphate or fumerate can be given. A computerized literature search using MEDLINE was conducted for publ …. Abstract. Oral manifestations of leukemia are well documented and may often represent the first sign, as primary lesions (gingival and bone neoplastic infiltrations) or secondary to pancytopenia (gingival bleeding, necrotic ulcerations 1. leukemic infiltrates cause a wide range of oral disease. Arunkumar KV, Kumar S, Deepa D. Brown tumor in mandible as a first sign of vitamin 16:310-5. 1 The Journal of Contemporary Dental Practice, Volume 9, No. Academic Editor: Stephen D. H. Malnick. Bashal F. Hematological disorders in patients with systemic lupus erythematosus. Oral Lesions in Patients with Hematological Disorders or Cancer Middle East J Cancer 2020; 11(2): 192-197 193 such as anemia, thrombocytopenia, and neutropenia. The predominant clinical presentation of the oral lesions includes ulcers, papules and 4. Uthman AA, Perriman AO. [1] Most of these manifestations are non-specific, but should alert the hematologist and the dental surgeon to the possibilities of a concurrent hematological disorder or a latent one that may subsequently manifest itself. 2. Diabetes mellitus and oral manifestations e588 included in the review, four were longitudinal studies and 15 cross-sectional studies. Oral signs are frequently the first manifestation of autoimmune diseases. The main objective of this review is to create awareness among the dental professionals about the various oral manifestations of respiratory disorders, so that they diagnose it in a much earlier stages, for patient’s ultimate benefit. For bulimia nervosa, lifetime prevalence is 1 to 4.4%, with a male-to-female ratio of 1:20. 3. 2017 Sep 1;22 (5):e586-94. Indian J Dent Res 22(3): 454-461. The oral manifestations of Gaucher disease (GD) are often detected during routine dental radiographic examinations. Jun Murakami1 and Yukihiro Shimizu 2. Blood Adult: •Female 4-5L •Males 5-6L. Initial recognition of a bleeding disorder, which may indicate the presence of a systemic pathologic process, may occur 1: Hematological manifestations of Good syndrome. Dental management of patients with inherited bleeding disorders: a multidisciplinary approach 58 GENERAL DENTISTRY November/December 2017 (mild), type 2 (moderate), and type 3 (severe).20,33,34 This classifi- cation is In addition to the cutaneous and systemic findings, the mucous membranes, periodontal tissues, salivary glands, and perioral tissues are often impacted. Hematologic disorders. Key words: l eukocyte alterations, oral manifestations, dental management. The frequency of hematological disorders in SLE are the highest among all other manifestations in Saudi Arabia []. Start studying Oral Manifestations of Hematological Disorders Part 1. penia (and the less common disorders periodic chronic myelogenous leukemia, periodic auto-immune hemolytic anemia, polycythemia vera, aplastic anemia, and cyclical They result in nervous system dysfunction through a variety of mechanisms, including vascular occlusion, hemorrhage, infiltration and metabolic disturbance, which may be hereditary or acquired. 2011;3(3):e246-50. (2011) Orofacial manifestations of hematological disorders: Anemia and hemostatic disorders. Transport of: › Gases, nutrients, waste products › Processed molecules › Regulatory molecules Regulation of pH and osmosis Maintenance of body temperature Protection against foreign substances Clot formation. 2. Typical oral manifestations of acute leukaemias include gingival swelling, oral ulceration, spontaneous gingival bleeding, petechiae, mucosal pallor, herpetic infections and Manifestations of systemic lupus erythematosus. 2011; 15:S113-6. The most frequent intra‐oral manifestations are dental erosion, trauma to the mucosa of the oral cavity and pharynx, dry mouth, a heightened risk of caries, periodontal problems, and lesions to the soft tissues secondary to the emesis, or effects induced indirectly by vomiting systemically [ 1 ]. The oral and dental manifestations of the calcium metabolism disorders such as hypophosphatemic vitamin D resistant rickets have been well described in the literature [23-25]. Oral Lesions in Patients with Hematological Disorders or Cancer Middle East J Cancer 2020; 11(2): 192-197 193 such as anemia, thrombocytopenia, and neutropenia. Oral manifestations of hematologic and nutritional deficiencies can affect the mucous membranes, teeth, periodontal tissues, salivary glands, and perioral skin. Electronic address: christina.mccord@schulich.uwo.ca. Oral manifestations of hepatitis B and C: A case series with review of literature _____Bagewadi SB,et al. 1Division of Oral Pathology, Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond Street, HSA 418A, London, Ontario N6A 5C1, Canada. Pemphigus vulgaris and mucous membrane pemphigoid. Of these, 14 (74%) found a higher Requirement of iron in … Oral manifestations of leukemia are well documented and may often represent the first sign, as primary lesions (gingival and bone neoplastic infiltrations) or secondary to pancytopenia (gingival bleeding, necrotic ulcerations 1. Read the latest articles of Atlas of the Oral and Maxillofacial Surgery Clinics at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature Receive an update when the latest issues in this journal are published Oral manifestations of nutritional disorders Stanislav N. Tolkachjov, MD, Alison J. Bruce, MD⁎ Department of Dermatology, Mayo Clinic, Rochester, MN Abstract Nutritional deficiencies occur when body metabolic requirements are 3. Acute myeloid leukemia (AML) is a heterogeneous group of diseases, whose classification is based on lineage-commitment and genetics. Orofacial manifestations of hematological disorders: Anemia and hemostatic disorders May 2011 Indian journal of dental research: official publication of Indian Society for Dental Research 22(3):454-61 Soft tissue findings Oral mucosa: Common reported manifestations in oral mucosa include mucosal pallor or erythema, ulcerations, hemorrhage, mucositis, severe recurrent viral, bacterial and fungal oral infection. Hepatic Manifestations in Hematological Disorders. hematological disorders in relation to occupations Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. A … A computerized literature search using … Oral manifestations of hematologic and nutritional deficiencies can affect the mucous membranes, teeth, periodontal tissues, salivary glands, and perioral skin. anemia & other blood disease and its manifestations in oral cavity 1. increased bilirubin production secondary to hemolysis. The symptoms include gingival enlargement and bleeding, oral ulceration, petechia, mucosal pallor, noma Unusual changes in oral tissues such as color or texture variations, bleeding tendencies, swelling, ulcerations, necrosis, lymph node enlargements and atypical bone findings may be manifestations of a … Start studying Oral Manifestations of Hematological Disorders Part 1. Indeed, an early diagnosis can play a decisive role in improving the … Skin manifestations of haematological diseases, Blood disorders. Eating disorders occur primarily in women, who comprise 90% of patients affected. Hematologic disorders can affect the central and peripheral nervous systems in a number of different ways, producing a wide range of neurologic disturbances. infection. Visual disorders (79.5%) were the most common. Practical step-wise approach to understanding and investigating anemia and bleeding disorders is illustrated. Oral care providers must be aware of the impact of bleeding disorders on the manage-ment of dental patients. Oral manifestations of systemic disease 24 GENERAL DENTISTRY November/December 2017 or absent, and the oral mucosa may be dry, red, and wrinkled.4 The … Oral manifestations of hematological disorders. Report of four cases. Oral manifestations occur frequently in leukemic patients and may present as initial evidence of the disease or its relapse. Authoritative facts from DermNet New Zealand. Oral candidosis is very common in HIV-positive individuals and almost universal in AIDS [14]. The oral manifestations of hematologic disorders are variable and sometimes resemble other local or systemic conditions. KEY WORDS: Pulmonary disorders, dental service, oral cavity, References. Management of the Hematological Manifestations of HIV Infection and AIDS places the patient at increased risk for bleeding and requires frequent platelet counts (Brager & Yasko). Most common cause of anemia in the world. International Journal of Scientific and Research Publications, Volume 2, Issue 9, September 2012 1 ISSN 2250-3153 www.ijsrp.org Hematological Changes in Chronic Renal Failure Suresh M* **, Mallikarjuna reddy N , Sharan B Singh M**, Hari Krishna Bandi***,Shravya keerthi G**, 1973 Jan;39 (1):27-8. Anemic disorders associated with orofacial signs and symptoms include iron deficiency anemia, Plummer-Vinson syndrome, megaloblastic anemia, sickle cell anemia, thalassaemia and aplastic anemia. • Oral manifestations of gastrointestinal diseases. HEMATOLOGIC (BLOOD) DISEASES • Bleeding Disorders – Platelet Function – Coagulation Factor • Platelet Deficiency – Thrombocytopenia / Thrombocytopathia • Red Blood Cell (RBC) Disorders – Anemia • White Blood Cell (WBC) Disorders – – – Leukopenia Leukemia … Kaposi s Sarcoma KS is one of the oral manifestations that is strongly associated with HIV, although its prevalence is quite low in this group Ceballos-Salobrena et al., , Studies from the USA Patton et al., and Mexico Ramírez-Amador et al., found no sig‐ nificant change in … e247 J Clin Exp Dent. tendency to ulcerate. It focuses upon oral mucosal and salivary I gland disorders that may arise as a consequence of systemic disease. Disorders of almost any body system can adversely impact upon the mouth. Sirois D et al (1993) Oral manifestations of cutaneous T-cell lymphoma a report of eight cases Oral Surg Oral Med Oral Pathol 75(6) 700–5 DOI: 10.1016/0030-4220(93)90426-5 PMID: 8515982 42. In the US iron deficiency in men J Dent Specialities, 2015;3(1):96-101 97 Fig.1: A 40 years old female with angular chelitis and spontaneous bleeding from lips. In addition to the cutaneous and systemic findings, the mucous membranes, periodontal tissues, salivary glands, and perioral tissues are often impacted. The majority of oral health conditions are: dental caries (tooth decay), periodontal diseases, oral cancers, oral manifestations of HIV, oro-dental trauma, cleft lip and palate, and noma (severe gangrenous disease starting in the mouth mostly affecting children). 1The Third Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan. Oral manifestations of endocrine problems 1. Hemoglobin levels of … If you continue browsing the site, you agree to the use of cookies on this website. Oral manifestations of endocrine problems 1. 2. Although rare in childhood, it is the most common type of acute leukemia in adults, accounting for 80% of all cases in this age group. J Dent Specialities, 2015;3(1):96-101 97 Fig.1: A 40 years old female with angular chelitis and spontaneous bleeding from lips. To detect the presence of eating disorders (EDs) and clinical findings in 20-25 years old women residing in professional college hostels in Bangalore city, India, a cross-sectional study was conducted. Indian J Endocr Indian J Endocr Metab [serial online] 2011 [cited 2015 May 10];15, Suppl S2:113-6. Specific search for these signs should be a part of all routine physical examinations. blood. 9. oral and facial manifestations presented in (Figure 1). The aim of this review is to offer readers practical advice concerning the onset, diagnosis and treatment of the main oral manifestations encountered in rheumatological and dental clinics. Background Oral manifestations may be the first signs of hematologic diseases, and may occur due to the disease itself or to treatment. chapter 17 Care of Patients with Hematologic Disorders Objectives Theory 1. Hematological disorders were reported in 82.7% of patients with SLE in a study conducted in Saudi Arabia Thus, a basic understanding of the oral complica-tions of hematologic disease is an essential part of patient care. Unusual changes in oral tissues such as color or texture variations, bleeding tendencies, swelling, ulcerations, necrosis, lymph node enlargements and atypical bone findings may be manifestations of a serious hematopoietic disorder. Hematologic disorders can affect the central and peripheral nervous systems in a number of different ways, producing a wide range of neurologic disturbances. e present review describe the elementary lesions observed in the oral cavity in cases of bleeding syndromes and disorders of blood erythroid series. A number of oral manifestations of systemic disease have been covered previously5, 6 ; … Jaundice is common hepatic manifestations, including infarction, hemorrhage, in patients with DIC and may be due to liver injury and and rupture. Chandna S, Bathla M. Oral manifestations of thyroid disorders and its management Indian J Endocr Metab. The prevalence of other oral and facial MS manifestations included dysarthria (44.3%), dysphagia (21%), facial palsy (15% Indeed, an early diagnosis can play a decisive role in improving the quality of treatment strategies as well as quality of life. Oral and maxillo-facial manifestations of systemic diseases represent an extensive and fascinating study, which is mainly based on the knowledge that many signs and symptoms as numerous systemic disorders may first The article seeks to provide realistic information for the first-contact physician in handling common hematological diseases in children. Introduction The treatment of oral mucosal disorders must be based on an early and correct diagnosis. Oral manifestations: - erythema of oral mucosa, glossitis, gingivitis, gingival bleeds spontaneously but no. The aim of this paper is to review the literature and identify orofacial manifestations of hematological diseases with special reference to hemato-oncologic, immuno-deficiency disorders, and human immunodeficiency virus infection. This article provides a guide for recognizing the oral manifestations of select systemic diseases. Anemia and other blood diseases 2. The objective of this article is to review the literature concerning the oral manifestations and the considerations that must factor in the dental treatment of patients with leukocyte alterations. White blood cell disorders Lymphoma Lymphomas include a diverse group of hematological malig thyroid diseases, mental disorders etc. Eating disorders are also characterized by intra‐oral and extra‐oral manifestations. Typical oral manifestations of acute leukaemias include gingival swelling, oral ulceration, spontaneous gingival bleeding, petechiae, mucosal pallor, herpetic infections and Autoimmune disease may manifest as oral ulcerations, changes in the salivary and parotid glands, and changes in the tongue. Dental management of patients with inherited bleeding disorders: a multidisciplinary approach 58 GENERAL DENTISTRY November/December 2017 (mild), type 2 (moderate), and type 3 (severe).20,33,34 This classifi- cation is 32 These include loss of alveolar bone trabecular architecture, widening of bone marrow spaces, and presence of Number of times cited according to CrossRef: 1 Michiko Sasaki, Takashi Matsuura, Michitsuna Katafuchi, Kentaro Tokutomi, Hironobu Sato, Higher Contents of Mineral and Collagen but Lower of Hydroxylysine of Collagen in Mandibular Bone Compared with Those of Humeral and Femoral Bones in Human, Journal of Hard Tissue Biology, 10.2485/jhtb.19.175, 19, 3, (175-180), (2010). Specific or non-specific oral manifestations of individual myeloid neoplasms that have oral manifestation are discussed below. Key words: dental management, endocrine disorders, oral manifestations. Objetives The aim of this article was to perform a literature review about: 1. For this reason, dentists play an important role in the detection of emerging autoimmune pathologies. leukemic infiltrates cause a wide range of oral disease. Oral manifestations of hepatitis B and C: A case series with review of literature _____Bagewadi SB,et al. Secondary oral manifestations of leukemia include signs due to the suppression of normal hematopoietic bone marrow (anemia, leucopoenia, thrombocytopenia) such as generalized mucosal pallor, non-specific oral erythema or cyanosis, erosions and usually painful or even necrotic ulcerations caused by small vessels thrombosis from leukemic cells or by the diminished local … For anorexia nervosa, the lifetime prevalence is 0.5 to 1.5%, and the male-to-female ratio is 1:10. 3. Ranginwala AM, Chalishazar Affiliations. Anemic disorders associated with orofacial signs and symptoms include iron deficiency anemia, Plummer-Vinson syndrome, megaloblastic anemia, sickle cell anemia, thalassaemia and aplastic anemia. Chandna S, Bathla M. Oral manifestations of thyroid disorders and its management Indian J Endocr Metab. penia (and the less common disorders periodic chronic myelogenous leukemia, periodic auto-immune hemolytic anemia, polycythemia vera, aplastic anemia, and cyclical Systemic diseases with oral findings include autoimmune, hematologic, endocrine, and neoplastic processes. Objective: To review the literature on the main types of anemic disorders and their orofacial manifestations, considering the Beside this, newborns and children with DS may also develop several hematological problems such neutrophilia, thrombocytopenia, polycythemia etc. ORAL MANIFESTATIONS OF ENDOCRINE PROBLEMS ARSALAN WAHID MALIK 2. ORAL MANIFESTATIONS OF ENDOCRINE PROBLEMS ARSALAN WAHID MALIK 2. Orofacial manifestations of hematological disorders: Anemia and hemostatic disorders Titilope A Adeyemo , Wasiu L Adeyemo , Adewumi Adediran , Abd Jaleel A Akinbami , Alani S Akanmu Departments of Haematology and Blood Transfusion and Oral and Maxillofacial Surgery, College of Medicine, University of Lagos, Nigeria N Y State Dent J. 6. Oral hygiene: Oral hygiene includes brushing of the teeth and tongue two to three times daily with regular soft nylon brush or electric toothbrush, regardless of the hematological status. Initial recognition of a bleeding disorder, which may indicate the presence of a systemic pathologic process, may occur
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